Concepedia

Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E.

David M. Balitz, F. A. O''HERRON, J. Bush, D. M. VYAS, Donald E. Nettleton, Robert Grulich, William T. Bradner, Terrence W. Doyle, Eddy Arnold, Jon Clardy

The Journal of Antibiotics · 1981 · 78 citations · 9 references

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Abstract

The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilvocarcin V demonstrated potential as an antitumor agent.

References

9

Gilvocarcins, new antitumor antibiotics. 2. Structural elucidation.

Keiichi Takahashi, Mayumi Yoshida, Fusao Tomita et al. · The Journal of Antibiotics · 1981 · 97 citations · Full text

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Use of negative quartet cosine invariants as a phasing figure of merit: NQEST

G. T. De Titta, J. Edmonds, D. A. Langs et al. · Acta Crystallographica Section A · 1975 · 96 citations

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Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities.

Hirofumi Nakano, Yuzuru Matsuda, Kunio Ito et al. · The Journal of Antibiotics · 1981 · 90 citations

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Crystal and Molecular Structure of Antibiotic Gilvocarcin M

Noriaki Hirayama, Keiichi Takahashi, Kunikatsu Shirahata et al. · Bulletin of the Chemical Society of Japan · 1981 · 43 citations

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Toromycin, a new antibiotic produced by Streptomyces collinus subsp. albescens subsp. nov.

Kazunori Hatano, Eiji Higashide, Motoo Shibata et al. · Agricultural and Biological Chemistry · 1980 · 30 citations · Full text

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