Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E.

Abstract

The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilvocarcin V demonstrated potential as an antitumor agent.