Indian Journal of Ophthalmology · 2014 · 45 citations · 17 references
MedicineImmunologyOphthalmologyInflammationOcular DiseaseOcular ImmunologyDiabetic RetinopathyEye DiseaseImmunopathology Of The EyeOcular Cytokine BiologyOcular InflammationRetinal ImmunologyControl Group DesignCytokine Signaling At The Blood-retinal BarrierDiabetic Retinopathy CytokinesDiabetic Retinopathy ImmunologyDiabetic Retinopathy ProgressionMatched Control GroupVitreous Cytokines
PURPOSE: To determine the roles of interleukin (IL)-1β and IL-10 in the vitreous of proliferative diabetic retinopathy (PDR). MATERIALS AND METHODS: Vitreous samples were obtained from 26 eyes of 26 patients with PDR and from eight eyes of eight cases without PDR. The IL-1β and IL-10 concentration in the vitreous was measured by using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Levels of IL-1β and IL-10 in vitreous were higher in PDR patients compared with control group. And there was significantly negative correlation between IL-1β and IL-10 in control group (r = -0.795; P = 0.032), whereas there was no significant correlation in PDR group (r = 0.176; P = 0.391). CONCLUSION: Levels of IL-1β and IL-10 were upregulated in vitreous of PDR patients, and these two cytokines play roles in regulating the development and progression of PDR.
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