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Immunohistochemical Expression of Epidermal Growth Factor Receptors in Nuclei of a Subpopulation of Keratinocytes and Sweat Gland Cells
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1991
Year
Nuclear LabellingPolyclonal AntibodyCell ProliferationDermatologyCell GrowthCellular PhysiologyImmunohistochemical ExpressionExperimental DermatologyCell SignalingIntercellular PatternSkin DevelopmentCutaneous BiologyHistopathologyDermatopathologyCell BiologyDevelopmental BiologySignal TransductionSweat Gland CellsMedicineDermal StructureExtracellular Matrix
We have raised a polyclonal antibody to the 170-kD epidermal growth factor receptor. We found an intercellular pattern of immunoreactivity in the epidermis as well as a positivity of the cytoplasm of keratinocytes and eccrine secretory cells. In some samples, a nuclear labelling was evidenced in these type of cells. There is a close resemblance in the topographical distribution of these cells with nuclear labelling and those synthesizing DNA under phytohaemagglutinin stimulation.