Development and optimization of industrial scale chromatography for use in manufacturing

Abstract

arly use of large scale low pressure chromatography came from developments in Manhattan Project and the fractionation of petroleum distillates and the separation of sugars The development of high performance p rocess ch ro m at ograp hy for industrial or manu fa c t u ri n g applications has steadily evolved over the last 10 years. The growth of the pharmaceutical industry and the need to develop and manufacture high purity bulk pharmaceutical products created a demand for the use of chromatography as a manufacturing unit operation The commercialization of large scale integrated equipment with pumps, c o l u m n s and detectors and improved packing media, has provided an ava i l able supply of hardwa re to meet the demand Recently, the entry of many new manufacturers of columns, packing media, industrial detectors and automation software i n c reased the selection of ch ro m at ograp hy equipment. However, this also requires a greater understanding of the issues surrounding making choices of equipment and packing media.