Concepedia

Synthesis of Morpholin-2-ones by Chemoselective Intramolecular Rhodium-Catalyzed Reductive Ring Expansion of Oxazolidines

Maksym Vasylyev, Howard Alper

Organic Letters · 2008 · 29 citations · 12 references

DOI

Concepts

Abstract

The rhodium-catalyzed reductive intramolecular ring expansion of N-(ethoxycarboxymethyl)oxazolidines was carried out under an atmosphere of carbon monoxide and hydrogen to afford N-methylmorpholin-2-ones in good to excellent yields.

References

12

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Inversion of Stereochemistry in the Co<sub>2</sub>(CO)<sub>8</sub>-Catalyzed Carbonylation of Aziridines to β-Lactams. The First Synthesis of Highly Strained <i>trans</i>-Bicyclic β-Lactams

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