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Structure-Activity Relationships of Flavonoids<i>,</i>Isolated from<i>Scutellaria baicalensis,</i>Binding to Benzodiazepine Site of GABA<sub>A</sub>Receptor Complex

DOI

36

Citations

0

References

2002

Year

Hongyan Wang, Kwok‐Min Hui, Yingjie Chen, Suixu Xu, J. Tze‐Fei Wong, Hong Xue
Planta Medica

Abstract

Twenty-six flavonoids were isolated from Scutellaria baicalensis. Their affinities for the benzodiazepine (BDZ) binding site of GABA A receptor have been studied using [ 3H]flunitrazepam binding to rat cortical membranes in vitro. The structure-activity relationships suggested that 2'-OH flavones exhibited the most potent binding affinity, which could lead to the design and discovery of new BDZ receptor ligands.