Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

Yan Zhou, C H Damsky, Susan J. Fisher · Journal of Clinical Investigation · 1997 · 939 citations · Full text

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E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

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Interactions between Trophoblast Cells and the Maternal and Fetal Circulation in the Mouse Placenta

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Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain

Shigemi Hayashi, Paula Lewis, Larysa Pevny et al. · Mechanisms of Development · 2002 · 516 citations

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Developmental and adult phenotyping directly from mutant embryonic stem cells

Sophia George, Marina Gertsenstein, Kristina Vintersten et al. · Proceedings of the National Academy of Sciences · 2007 · 287 citations

Life Sciences, Biology, Genetics +13