Publication | Closed Access
THE CALORIGENIC ACTION OF EXTRACTS OF THE ANTERIOR LOBE OF THE PITUITARY IN MAN1
15
Citations
0
References
1936
Year
Organic IodineAdrenal GlandPituitary GlandIodine Deficiency DisordersNeuroendocrine MechanismPituitary DiseasePublic HealthAnimal PhysiologyEndocrine MechanismNervous SystemBasal Metabolic RateEndocrinologyNeuroanatomyThe Anterior LobePhysiologyThyroid DiseaseActive Pituitary ExtractsThyroid DisordersThyroid HormoneMetabolismMedicineEndocrine Disease
The present series of observations represents an attempt to reproduce in man results which have been observed in animals during the administration of extracts of the anterior lobe of the pituitary containing the so-called thyrotropic principle.3 Abundant evidence of the relationship between the pituitary and the thyroid has been obtained in animals and in man and has been summarized in recent articles by Evans (3), (4), Smith (5) and Collip (6), (7). The following facts have been demonstrated. 1. Enlargement of the pituitary has been noted in thyroidectomized animals and in patients with cretinism and myxedema. 2. The thyroid becomes atrophic and the basal metabolism drops following removal of the pituitary. 3. The administration of active pituitary extracts to animals causes, temporarily;(a) hyperplasia of the thyroid, (b) reduction in the iodine content of the gland, (c) increase in the organic iodine of the blood, (d) tachycardia, (e) exophthalmos, (f) increase in basal metabolic rate. These changes do not occur in thyroidectomized animals.