Effect of eugenol on animal models of nociception

Abstract

<b>Objective:</b> To investigate the antinociceptive potential of eugenol on different pain models in mice. <br><b> Materials and Methods</b> : Eugenol was evaluated (1-100 mg/kg, i.p.) in various experimentally induced pain models like, formalin induced hyperalgesia, acetic acid induced abdominal constrictions, and thermal pain experiment using Eddy's hot plate.<br><b> Results</b> : Eugenol significantly inhibited acetic acid induced abdominal constrictions, with the maximal effect (92.73% inhibition) at 100 mg/kg. In formalin induced paw licking pain model, eugenol exhibited more pronounced antinociceptive effect in the inflammatory phase than the neurogenic phase (maximal effect was 70.33% and 42.22%, respectively, at 100 mg/kg, i.p). A mild reduction in the pain response latency at 100 mg/kg, i.p. dose of eugenol was observed in the hotplate thermal pain studies in mice. In the rotarod motor coordination experiment eugenol reduced the endurance time at the dose of 100 mg/kg, i.p. <br><b> Conclusion:</b> The data suggest that eugenol exerts antinociceptive activity in different experimental models of pain in mice.