<i>Helicobacter pylori</i> CagA Status, Mucosal Oxidative Damage and Gastritis Phenotype: A Potential Pathway to Cancer?

Abstract

cagA-positive patients were characterized: first, for higher scores for gastritis, activity and atrophic and metaplastic lesions; and second for greater oxidative DNA damage overall, at younger age and in the presence of multifocal atrophy. This setting may represent a cancer-prone biological context.