Concepedia

Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor β1 in cultured normal human fibroblasts

Xiaodong Zhou, Filemon K. Tan, Xinjian Guo, Debra D. Wallis, Dianna M. Milewicz, Sarah Xue, Frank C. Arnett

Arthritis & Rheumatism · 2005 · 40 citations · 17 references

DOI

Abstract

TGFbeta1 can induce increased expression of both SPARC and type I collagen. Specific inhibition of SPARC led to decreased expression of type I collagen and attenuated the profibrotic effect of TGFbeta1 in cultured normal human fibroblasts. Use of siRNA to silence SPARC represents a potential therapeutic approach to fibrotic disorders such as scleroderma.

References

17

Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques

C.R. Dhore, Jack P.M. Cleutjens, Esther Lutgens et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2001 · 704 citations · Full text

, , +24

The biology of SPARC, a protein that modulates cell‐matrix interactions

Timothy F. Lane, E. Helene Sage · The FASEB Journal · 1994 · 538 citations

Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins

Larry W. Fisher, John T. Stubbs, Marian F. Young · Acta Orthopaedica Scandinavica · 1995 · 448 citations · Full text

, , +10

The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

Elaine W. Raines, Timothy F. Lane, M. Luisa Iruela‐Arispe et al. · Proceedings of the National Academy of Sciences · 1992 · 361 citations

, , +19

SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-β1 in Mesangial Cells

Aleksandar Francki, Amy D. Bradshaw, James A. Bassuk et al. · Journal of Biological Chemistry · 1999 · 187 citations · Full text

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