European Neurology · 2003 · 15 citations · 5 references
EducationKinesiologyPhysiologyExercise PhysiologyExercise TestingPhysical ActivityCardiopulmonary Exercise TestingCycle Ergometer TestingMuscle Strength AssessmentMuscle Strength TestingMuscular Strength TestingPhysical FitnessCycle Ergometer Lactate TestingExercise Test ValidityLactate AccumulationMitochondrial MyopathiesRelative Muscle StrengthRelative StrengthScreening Test ValidityWorkload
The aim of this study was to evaluate the usefulness of a modification of the bicycle ergometer test, the subanaerobic threshold exercise test (SATET), as a screening test for patients with mitochondrial myopathies. Since the original SATET is frequently found to be strenuous for weak patients, a new variable (relative muscle strength) was added to the workload formula. Plasma lactate levels were recorded at rest, then after 5 and 15 min of cycling on an ergometer, with constant workload. Nine patients with mitochondrial myopathy, 10 patients with other neuromuscular diseases and 9 healthy but sedentary volunteers undertook the test. An upper reference limit after exercise for plasma lactate was settled at 2.9 mmol/l. The modified SATET showed a sensitivity of 78% and a specificity compared to the healthy subjects of 100%. Compared to patients with other neuromuscular diseases, the specificity was lower (60%). All subjects completed the test without severe fatigue or pain.
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A forearm exercise screening test for mitochondrial myopathy
Tina Dysgaard Jensen, Pedram Kazemi‐Esfarjani, E. Skomorowska et al. · Neurology · 2002 · 63 citations