TREATMENT OF SEXUAL UNDERDEVELOPMENT WITH SYNTHETIC MALE HORMONE SUBSTANCE1

Abstract

This report of a single case is deemed worthwhile because of 1) the lack of reports of similarly treated cases, 2) the very limited amount of synthetic male hormone that was available for this investigation, 3) the extensive study made of this individual before and after treatment, and 4) the wide bearing of these findings upon endocrine treatment of hypogenitalism, cryptorchidism, impotence, migraine, acne and menopausal symptoms. History and Examination. The patient was a 27-year-old white male medical student whose chief complaints were headache in right frontal and temporal regions, attacks of malaise, hot flushes, proneness to fatigue and social stigmata due to feminine aspect and high voice. In 1933 the patient received 3 injections of 1 cc. antuitrin-S weekly for a 3-week period, followed by 2 weeks of rest; this was continued for 3 months with but slight alleviation of symptoms. Save for similar menopausal symptoms of flushes and headaches in the mother, the family history was irrelevant. The patient had had measles, influenza complicated by pneumonia, chicken pox and scarlet fever before the age of 15. The organ systems except the endocrine, reproductive, osseous and integumentary were essentially normal.