Nicotine amplifies reward-related dopamine signals in striatum

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Medicine, Neuroscience, Pharmacology +17

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

Marina R. Picciotto, Michèle Zoli, Roberto Rimondini et al. · Nature · 1998 · 1.3K citations

Life Sciences, Neuroscience, Pharmacology +16

A cellular mechanism of reward-related learning

John N. J. Reynolds, Brian I. Hyland, Jeffery R. Wickens · Nature · 2001 · 899 citations

Medicine, Neurobiology, Neuroscience +14

Nicotine activates and desensitizes midbrain dopamine neurons

Volodymyr I. Pidoplichko, Mariella DeBiasi, John T. Williams et al. · Nature · 1997 · 763 citations

Life Sciences, Neuroscience, Pharmacology +14

Synaptic Mechanisms Underlie Nicotine-Induced Excitability of Brain Reward Areas

Huibert D. Mansvelder, J. Russel Keath, Daniel S. McGehee · Neuron · 2002 · 694 citations · Full text

Life Sciences, Neurobiology, Neuroscience +14