Gingival fibroblasts grown from cyclosporin‐treated patients show a reduced production of matrix metalloproteinase‐1 (MMP‐1) compared with normal gingival fibroblasts, and cyclosporin down‐regulates the production of MMP‐1 stimulated by pro‐inflammatory cytokines

Abstract

Pro-inflammatory cytokines significantly up-regulate MMP-1 in cultured gingival fibroblasts. Up-regulation is attenuated by both cyclosporin and nifedipine. The interaction may account for the synergism between inflammation and cyclosporin-induced gingival overgrowth.