Opposing Roles of p47 ^phox in Basal Versus Angiotensin II–Stimulated Alterations in Vascular O ₂ ⁻ Production, Vascular Tone, and Mitogen-Activated Protein Kinase Activation

Abstract

p47phox plays a complex dual role in the vasculature. It inhibits basal NADPH oxidase activity but is critical for Ang II-induced vascular dysfunction via activation of NADPH oxidase.