Abnormal regulation of G protein αi2 subunit in skin fibroblasts from insulin-resistant hypertensive individuals

Abstract

A subnormal Galpha(i2)-mediated signal transduction may be involved in the pathogenesis of cellular insulin resistance in hypertension. This novel Galpha(i2)-mediated signal transduction associated with insulin sensitivity in fibroblasts may help to control excessive angiotensin II signalling.