Deletion of the <scp>RUNX</scp>1 binding site in the erythroid cell‐specific regulatory element of the <scp>ABO</scp> gene in two individuals with the <scp>A</scp>_m phenotype

Abstract

Deletion of the 23-bp nucleotides including the RUNX1 binding site decreases transcription of the A allele, resulting in the reduction in A antigen expression in the Am phenotype.