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Effects of <i>Panax ginseng</i> on glial cell‐derived neurotrophic factor (GDNF) expression and spermatogenesis in rats
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2010
Year
SpermatogenesisFertilityFemale Reproductive FunctionSemen AnalysisReproductive BiologyAbstract Panax GinsengMale InfertilityGerm Cell DevelopmentGametogenesisReproductive MedicineNeurotrophic FactorPublic HealthSperm AnalysisInfertilityAndrologyMolecular NeuroscienceNeuroprotectionSperm Formation PeriodPharmacologyCell BiologyDevelopmental BiologyGerm CellMedicine
Abstract Panax ginseng (PG) is a medicinal herb which has been used to improve male reproduction in traditional Korean medicine. This study investigated the effect of PG on spermatogenesis and the regulation of glial cell‐derived neurotrophic factor (GDNF), which has a crucial role in spermatogonial stem cell maintenance. PG was administered to 8‐week‐old male Wistar rats (1.0 g/kg/day, p.o.) for 56 consecutive days, the sperm formation period of the rat. Sperm analysis, RT‐PCR and western blot assays were then carried out. The PG‐treated group had significantly enhanced sperm counts, GDNF mRNA level and protein level. These results suggest that PG induces spermatogenesis and GDNF activation in rat testes. Copyright © 2010 John Wiley & Sons, Ltd.
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