Generation of<i>Cre</i>Transgenic Mice with Postnatal RPE-Specific Ocular Expression

Abstract

This BEST1-cre transgenic line enables generation of RPE-specific knockout mice. The mosaic expression pattern provides an internal control; the non-cre-expressing RPE cells continue to express the floxed genes. These mice should facilitate study of the multifunctional RPE and the generation of mouse models of human retinal disease.