Tramadol Has No Effect on Cortical Renal Blood Flow—Despite Increased Serum Catecholamine Levels—in Anesthetized Rats: Implications for Analgesia in Renal Insufficiency

Abstract

A bolus and continuous injection of tramadol does not alter renal blood flow (RBF) in normal rats. A bolus injection of tramadol has little effect on RBF in rats with experimentally induced renal insufficiency. These results suggest that tramadol would be a safe analgesic for maintaining RBF during the postoperative period.