A comparative study of ethanol extract of leaves of<i>Tephrosia purpurea</i>pers and the flavonoid isolated for hepatoprotective activity

Abstract

Ethanol extract of leaves and flavonoid (isolated from leaves extract) from Tephrosia purpurea were evaluated for hepatoprotective activity in rats by inducing hepatotoxicity with carbon tetrachloride. These fractions were administered orally at a dose of 100 mg/kg/day. Serum level of transaminases, alkaline phosphate, and total bilirubin were used as biochemical markers of hepatotoxicity. Histopathological changes in the liver were also studied. The results of the study indicated that the hepatoprotective activity was more in ethanolic extract of leaves than isolated flavonoid.