“Endogenous adjuvant” activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60

Abstract

We conclude that the RNA components of the Ro 60 (Y1-Y5 RNA) and Sm/RNP (U1 RNA) small ribonucleoproteins act as endogenous adjuvants that could play a role in the pathogenesis of autoimmunity by stimulating DC maturation and IFN-I production.