The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia‐associated transcription factor (MITF) and other melanogenesis‐related proteins in normal and pathological skin, hair follicles and melanocytic nevi

Abstract

By CISH, TRPM1 mRNA expression is specific for melanocytes and strongly associated with MITF and tyrosinase expression, the latter implicating a mature melanocyte phenotype. However, in normal skin, TRPM1 mRNA expression appears to be dynamic, labeling most but not all melanocytes, with variable expression ostensibly related to local environmental factors.