Synthesis of some Thiochromone Derivatives and Activity Against <I>Plasmodium falciparum</I> In-vitro

Abstract

A series of thiochromone derivatives were synthesized from 3-cyano-2-methylthio-1-thiocromone with hydrazine and guanidine derivatives, and tested for antimalarial activity. Pyrimethamine was used as a reference drug. 3-Amino-[1]-benzothiopyran-[2,3-c]-pyrazol-4-one showed significant antimalarial activity against Plasmodium falciparum in-vitro. The remaining compounds had only modest activity.