Activation of nuclear factor‐kappa B correlates with tumor necrosis factor‐alpha in oral lichen planus: a clinicopathologic study in atrophic‐erosive and reticular form

Abstract

Nuclear factor-kappa B activation and its correlation with overexpression of TNF-alpha may play an important role in pathogenesis of OLP. There might be a positive regulatory loop between NF-kappaB and TNF-alpha, which may contribute to inflammation in OLP; NF-kappaB may also protect epithelial keratinocytes from excessive apoptosis.