THE USE OF SN-10,275 IN THE PROPHYLAXIS AND TREATMENT OF SPOROZOITE-INDUCED VIV AX MALARIA (CHESSON STRAIN) 1

Abstract

A large number of piperidyl quinolinemethanols were investigated for antimalarial activity in avian infections because of close chemical similarity to quinine, as part of the wartime search for new and more effective antimalarial agents. In preliminary observations, SN-10,275,3 or 6,8-dichloro-2- phenyl-a-2-piperidyl4-quinolinemethanol (Figure It is a compound of the Ainley-King series, which has a high degree of antimalarial activity in cathemerium and lophurae malaria in the duck and moderate ac- tivity in gallinaceum and lophurae malaria in the chick ( 1 ).