IgE Sensitization to <i>Aspergillus fumigatus</i> Is Associated with Reduced Lung Function in Asthma

Abstract

A. fumigatus detection in sputum is associated with A. fumigatus-IgE sensitization, neutrophilic airway inflammation, and reduced lung function. This supports the concept that development of fixed airflow obstruction in asthma is consequent upon the damaging effects of airway colonization with A. fumigatus.