Preliminary Observations on Management of Diabetes with "Stabinol"

Abstract

The management of diabetes by oral preparations has now become commonplace in many countries throughout the world. The literature on this subject is voluminous and the drugs in use have been given to more than half a million diabetics. Of all the hypoglycaemic agents tolbutamide has been the most widely used, and to date has the smallest incidence of abnormal side-effects. Mehnert et al. (1958), in a recent review of the use of tolbutamide on a group of 1,030 patients for a period of 1 to 20 months, demonstrated that it produced good control on 52.6% and fair control on an additional 18.5%. They found it to be an effective hypoglycaemic agent in 86%, but therapy had to be discontinued in 18% because of sideeffects affecting mainly the gastro-intestinal tract.