Concepedia

L-Type Ca <sup>2+</sup> Current Downregulation in Chronic Human Atrial Fibrillation Is Associated With Increased Activity of Protein Phosphatases

Torsten Christ, Stefan Wöhrl, Erich Wettwer, Eva Graf, Ralph Bosch, Michael Knaut, Wilhelm Schmitz, Ursula Ravens, Dobromir Dobrev

Circulation · 2004 · 294 citations · 28 references

DOIFull text

Open access

Abstract

In AF, increased protein phosphatase activity contributes to impaired basal I(Ca,L). We propose that protein phosphatases may be potential therapeutic targets for AF treatment.

References

28

Atrial Fibrillation Begets Atrial Fibrillation

M. C. E. F. Wijffels, C Kirchhof, Rick Dorland et al. · Circulation · 1995 · 3.5K citations

Ionic Remodeling Underlying Action Potential Changes in a Canine Model of Atrial Fibrillation

Lixia Yue, Jianlin Feng, Rania Gaspo et al. · Circulation Research · 1997 · 813 citations

Atrial L-Type Ca <sup>2+</sup> Currents and Human Atrial Fibrillation

David R. Van Wagoner, Amber Pond, Michelle Lamorgese et al. · Circulation Research · 1999 · 578 citations · Full text

Ionic mechanisms of electrical remodeling in human atrial fibrillation

Ralph Bosch · Cardiovascular Research · 1999 · 577 citations · Full text

A β <sub>2</sub> Adrenergic Receptor Signaling Complex Assembled with the Ca <sup>2+</sup> Channel Ca <sub>v</sub> 1.2

Monika A. Davare, Vladimir Avdonin, Duane D. Hall et al. · Science · 2001 · 512 citations

, , +17