NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

Anita Schuchardt, Vivette D. D’Agati, Lena Larsson-Blomberg et al. · Nature · 1994 · 1.6K citations

Signal Transduction, Receptor Tyrosine Kinase, Physiology +7

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

Marina P. Sánchez, Inmaculada Silos‐Santiago, Jonas Frisén et al. · Nature · 1996 · 1.2K citations

Urology, Mice Lacking Gdnf, Renal Function +13

GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys

Hideki Enomoto, Toshiyuki Araki, Alana Jackman et al. · Neuron · 1998 · 469 citations · Full text

Knockout Mouse, Molecular Physiology, Developmental Biology +12

Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation

Motozo Yamashita, Saixia Ying, Gen‐Mu Zhang et al. · Cell · 2005 · 357 citations · Full text

Sclerostin, Bone Morphogenic Protein, Cell Signaling +10

Sprouty1 Is a Critical Regulator of GDNF/RET-Mediated Kidney Induction

M. Albert Basson, Simge Akbulut, Judy Watson-Johnson et al. · Developmental Cell · 2005 · 357 citations · Full text

Urology, Renal Function, Medicine +7