Cytokine Tumor Necrosis Factor‐alpha A Promoter Gene Polymorphism at Position −308 G→A and Pediatric Inflammatory Bowel Disease

Abstract

Although not necessarily dictating IBD initiation, the TNF-alpha 308 A polymorphism may play a role in modifying the CD phenotype. The polymorphism may influence disease activity as well as more intense inflammatory activity in both forms of IBD and may modify the progression of chronic digestive tract inflammation.