Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

David S. Bredt, S H Snyder · Proceedings of the National Academy of Sciences · 1989 · 1.8K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

Richard G. Knowles, Richard Palmer, Salvador Moncada · Proceedings of the National Academy of Sciences · 1989 · 1.4K citations · Full text

Life Sciences, Biochemistry, Neurobiology +13

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

Medicine, Neuroscience, Pharmacology +17

SIMULTANEOUS QUANTITATIVE ASSESSMENT OF MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE

E. Leong Way, Fu-Hsiung Shen · Journal of Pharmacology and Experimental Therapeutics · 1969 · 680 citations

Medicine, Pharmacokinetics, Pharmacology +10

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

Radha Iyengar, Dennis J. Stuehr, Michael A. Marletta · Proceedings of the National Academy of Sciences · 1987 · 671 citations · Full text

Life Sciences, Immunology, Microbiology +13