METASTATIC CHORIONEPITHELIOMA OF LUNG WITH NITROGEN MUSTARD THERAPY

Abstract

CHORIONEPITHELIOMA, which technically should be hailed by its correct pathological appellation of choriocarcinoma, is a rare tumor of fetal origin which is highly malignant and rather bizarre in its action. According to Novak,¹50% follow in the wake of a previously existing hydatidi-form mole; 25% arise from abortion, and 25% originate from full-term pregnancies. Ectopic gestation, as well as a few reported teratomata from various sites, has also been reported as an etiological factor. A review of the literature, according to Mohler and McConnell,²reveals that approximately 2,000 cases have been reported. A statistical study by Novak¹reveals an incidence of choriocarcinoma in the neighborhood of 1 in every 150,000 to 200,000 pregnancies. Holman and Schurner,³in a review of 107 treated cases, noted the mortality to be 15% in those cases which were postmolar, and in those resulting from the stimulation of abortion and full-term