Dibenzyline: Results of Therapy in Patients with Hypertension and a Comparison with Hexamethonium, 1-Hydrazinophthalazine and Semipurified Extracts of Veratrum

Abstract

ALTHOUGH etiologic factors in hypertensive vascular disease are probably numerous, pharmacologic study indicates that in many cases a common denominator is overactivity of the sympathetic nervous system. Therefore, a drug that will specifically block the transmission of impulses over the sympathetic nervous system should be a valuable therapeutic agent for this disease. Dibenzyline (N-phenoxyisoprophyl-N-benzyl-β-chlorethylamine)¶ is a specific, orally active, adrenergic blocking agent that we have used in the treatment of 32 patients under hospital and outpatient conditions. A comparison of the results obtained with this drug and those obtained with hexamethonium, 1-hydrazinophthalazine (Apresoline) and the Veratrum viride alkaloids (Veriloid and . . .