Familial Thymic Aplasia

Abstract

A 10-week-old female infant with familial congenital thymic aplasia without delayed hypersensitivity to common skin-test antigens underwent fetal-thymus implantation. Six hours after the implantation of a fetal thymus enclosed in a Millipore chamber phytohemagglutinin responsiveness was demonstrable in the patient's peripheral lymphocytes. The infant's death of aspiration pneumonia nine days after implantation did not allow evaluation of the extent of the immunologic reconstitution. Thymic-cell immunologic function can be induced in man with fetal-thymus humoral factors.