Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-<b>α</b>: A description of a phase I-II protocol

Abstract

The protocol was well tolerated and was associated with antitumor activity in patients with a variety of advanced metastatic solid tumors. Tumor response occurred with the thermochemotherapy treatment despite treating malignancies that had progressed on the same chemotherapy drugs administered as standard treatment. Notably, good responses were observed in patients with high-grade neuroendocrine and pancreas cancers. This regimen will be tested in a phase II study.