Correlation of the Cytotoxicity of TiO₂ Nanoparticles with Different Particle Sizes on a Sub‐200‐nm Scale

Abstract

The size-mediated cytotoxicity of TiO2 nanoparticles is investigated at the cellular and molecular levels. The cytotoxicity dramatically increases around a particle size of 100 nm (nanoscale effect). This finding affords new insights into the cytotoxicity of nanomaterials, and has potential implications in the design of nanostructured biomaterials. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.