Autoanalgesia: Acquisition, blockade and relationship to opiate binding

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

F. E. D'Amour, Donn L. Smith · Journal of Pharmacology and Experimental Therapeutics · 1941 · 3.2K citations

Nursing, Pharmacology, Pain Management +14

Opiates and endogenous opioid peptides

John Kelly, Raymond Dingledine · Trends in Biochemical Sciences · 1977 · 1.3K citations

Medicine, Neuroscience, Pharmacology +12

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat

John J. Madden, Huda Akil, R. L. Patrick et al. · Nature · 1977 · 566 citations

Medicine, Neurobiology, Neuroscience +16