Blood-brain Barrier Disruption is Involved in Seizure and Hemianopsia in Nonketotic Hyperglycemia

Abstract

Delayed gadolinium enhancement was first observed in patients with acute infarction who underwent thrombolytic therapy, and it has been considered a marker of blood-brain barrier (BBB) disruption associated with reperfusion injury. Considering that increased BBB permeability is an important mechanism for neurologic complications in diabetes, and BBB leakage occurs during epileptogenesis and contributes to the progression of epilepsy in the chronic phase, we suggest that seizures in NKH patients may be a consequence of, or at minimum have an association with, hyperglycemia-induced BBB disruption.