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Simultaneous Simulation of the Serum Profiles of Two Antibiotics and Analysis of the Combined Effect against a Culture of <i>Pseudomonas aeruginos</i><i>a</i>
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1982
Year
Viable CountSerum ProfilesAntimicrobial ChemotherapyAntibiotic ResistanceDrug ResistanceSimultaneous SimulationMedical MicrobiologyInfection ControlClinical ChemistryAntimicrobial ResistanceCombined EffectHealth SciencesPseudomonas AeruginosaAntimicrobial PharmacokineticsClinical MicrobiologyAntimicrobial SusceptibilityAntibioticsMicrobiologyAntimicrobial PharmacodynamicsMedicineDiagnostic Microbiology
The serum profiles of ceftriaxone (CEF) and netilmicin (NET) were produced in a liquid culture of Pseudomonas aeruginosa, and the change in viable count recorded. Synergism was detectable between CEF and NET despite of the widely disparate serum halflife times of NET and CEF.