Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic‐Feeding Studies and Genetic Analysis

Abstract

Small wonder: Atrop-abyssomicin C is a small, yet complex spirotetronate (see scheme) that is active against Gram-positive bacteria, such as MRSA. Feeding studies and genetic manipulation of its producer, Verrucosispora maris AB-18-032, for the first time give insight into its biosynthesis and demonstrate how closely related the members of this important class of molecules are.