The Pediatric Infectious Disease Journal · 2009 · 31 citations · 9 references
PharmacyClinical PharmacokineticsPharmacokineticsClinical PharmacologyDrug ClearancePediatric Clinical PharmacologyInfant PharmacotherapyNeonatal Drug TherapyPediatric Antimicrobial TherapyPediatric Drug DosingPediatric PharmacokineticsPediatric PharmacologyDosing In Premature InfantsDrug Elimination Half-lifeNeonatal Clinical PharmacologyNeonatal DosingNeonatal Drug ClearancePharmacokinetics In InfancyPharmacokinetics In NeonatesRate Constant Determination
We evaluated the use of micafungin as a prophylaxis in very-low-birth-weight infants. Micafungin was first administered to 25 very-low-birth-weight infants 12 to 24 hours after birth at a dose of 1 mg/kg/d. the apparent volume of distribution, the apparent elimination rate constant, the elimination half-life, and the total body clearance (mean +/- SD) were 0.76 +/- 0.28 L/kg, 0.12 +/- 0.041 1/h, 6.7 +/- 2.2 h, and 0.089 +/- 0.047 L/kg/h, respectively.
9
A Multicenter, Randomized Trial of Prophylactic Fluconazole in Preterm Neonates
Paolo Manzoni, Ilaria Stolfi, Lorenza Pugni et al. · New England Journal of Medicine · 2007 · 359 citations · Full text
Medicine, Microbiology, Pediatrics +17