Effect of Carbon Dioxide and pH on Susceptibility of <i>Bacteroides fragilis</i> Group to Erythromycin

Abstract

We examined the effects of pH and incubation in a CO(2)-containing atmosphere on the activity of erythromycin against 81 strains of the Bacteroides fragilis group. A striking reduction in erythromycin activity was noted when the pH decreased below 7.0 and when the organisms were incubated with CO(2).