Archives of Disease in Childhood · 1978 · 10 citations · 1 references
PharmacyPediatricsSurgeryPediatric Clinical PharmacologyPediatric TherapeuticsVascular SurgeryAmputationInjection SafetyIntravenous Drug DeliveryPediatric Antibiotic TherapySafe Injection PracticesBenzathine Penicillin TherapyIntramuscular Injection SafetyIntramuscular Injection TechniqueIntramuscular Medication AdministrationIntravascular InjectionIntravenous Injection ComplicationsPediatric Intravenous Antibiotic TherapySafe Intravenous Injection
Accidental intra-arterial injection of intramuscular antibiotic preparations is described in 3 cases in infants. In 2 benzathine penicillin was injected, and in 1 rolitetracycline. The clinical features are dominated by arteriolar obstruction which produces gangrene of the most severely affected limb. In addition, neuroloigcal involvement occurs when vessels to nerves or spinal cord are involved. The arteriolateral aspect of the thigh is preferable to the buttock as a site for intramuscular injection, and a short (2.5 cm) needle should be used to minimise the risk of intra-arterial injection.
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