Annals of Human Biology · 2009 · 43 citations · 14 references
Life SciencesGeneticsMolecular GeneticsAutoimmunityHuman GeneticsImmunogeneticsAutoimmune Disease Susceptibility GenesDisease Susceptibility LociGenetic Susceptibility To AutoimmunityGenotype-phenotype Association AnalysisMolecular MarkersSystemic Lupus Erythematosus3' Untranslated Region AnalysisAutoimmune Disease GeneticsGenetic PolymorphismsHla Genotype AssociationsHla Polymorphism AnalysisHla Risk AllelesSingle Nucleotide Polymorphism Association Studies
In this study, we investigated the polymorphisms of the exon 1 (+49A/G), promoter sites (-1722T/C, -1661A/G, -318C/T), and 3'-untranslated region (3'-UTR) (+6230 A/G) of the CTLA-4 gene in systemic lupus erythematosus (SLE) affected patients. Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of these five markers in 130 SLE patients and 130 healthy controls. Of the five tested polymorphisms, there was no statistical significant difference between the genotypic and allelic frequencies of patients with SLE and controls. Hence, we propose that the CTLA-4 gene does not play a major role in the genetic susceptibility to the development of SLE in the Malaysian population.
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The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan, Alan S. Cohen, James F. Fries et al. · Arthritis & Rheumatism · 1982 · 14.6K citations
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
Hironori Ueda, Joanna M. M. Howson, Laura Esposito et al. · Nature · 2003 · 2.2K citations
Life Sciences, Genetics, Immunology +12
Katherine L. Harper, Christine Balzano, Éric Rouvier et al. · The Journal of Immunology · 1991 · 428 citations