The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control

One-step inactivation of chromosomal genes in <i>Escherichia coli</i> K-12 using PCR products

Kirill A. Datsenko, Barry L. Wanner · Proceedings of the National Academy of Sciences · 2000 · 15K citations · Full text

Construction of a genetic toggle switch in Escherichia coli

Timothy S. Gardner, Charles R. Cantor, James J. Collins · Nature · 2000 · 4.3K citations

Engineering, Genetic Engineering, Molecular Biology +7

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

Narasimhan Sudarsan, E. R. Lee, Zasha Weinberg et al. · Science · 2008 · 711 citations · Full text

Biology, Virulence Gene Expression, Natural Sciences +9

Identification of FleQ from <i>Pseudomonas aeruginosa</i> as a c‐di‐GMP‐responsive transcription factor

Jason W. Hickman, Caroline S. Harwood · Molecular Microbiology · 2008 · 645 citations · Full text

Analysis of <i>Pseudomonas aeruginosa</i> diguanylate cyclases and phosphodiesterases reveals a role for bis-(3′-5′)-cyclic-GMP in virulence

Hemantha Kulesekara, Vincent T. Lee, Anja Brenčič et al. · Proceedings of the National Academy of Sciences · 2006 · 531 citations · Full text

Cyclic Nucleotides, Biochemistry, Natural Sciences +12