Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

Life Sciences, Molecular Biology, Molecular Genetics +7

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science · 2002 · 4.3K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Reduced Expression of the <b> <i>let-7</i> </b> MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival

Junichi Takamizawa, Hiroyuki Konishi, Kiyoshi Yanagisawa et al. · Cancer Research · 2004 · 2.4K citations

Medicine, Molecular Biology, Oncology +17

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

Sen‐itiroh Hakomori · Journal of Biological Chemistry · 1990 · 884 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17