Journal of Reconstructive Microsurgery · 2003 · 62 citations · 0 references
MedicineNeurosurgerySurgeryMicrosurgeryPeripheral Nerve SurgeryWound HealingNerve GraftingNerve RegenerationNerve RepairNeural RegenerationPeripheral Nerve InjuryTissue RepairFibrin Glue Nerve RepairForeign Body Reaction To SuturesMicrosurgical Nerve AnastomosisMicrosurgical Nerve RepairNerve Defect ReconstructionNerve Graft DiameterPeripheral Nerve HistologySurgical Nerve Repair
The authors report the results of a comparative experimental nerve study, using a biologic tissue glue (fibrin) and a synthetic glue (2-cyanoacrylate) in a rat model. A tension-free repair is necessary with the use of fibrin glue, or gapping may occur, thus limiting the use of the agent in promoting re-neurotization. In addition, the human origin of fibrin and thrombin allow for the possibility of viral transmission. The aim of the study was to verify if the synthetic glue is a viable alternative, or whether it causes cellular and tissue lesions. Their main finding was that the cyanoacrylate causes a foreign-body inflammatory reaction and retractile fibrosis, often reducing the nerve diameter up to two-thirds. Cyanoacrylate glue is thus not recommended for peripheral nerve repair.