An N-hydroxylated derivative of cyanamide that inhibits yeast aldehyde dehydrogenase

Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals.

Akira Yoshida, I.Y. Huang, Michiharu Ikawa · Proceedings of the National Academy of Sciences · 1984 · 455 citations

Life Sciences, Biochemistry, Molecular Biology +13

A Statistically Precise and Relatively Simple Method of Estimating the Bio-Assay with Quantal Response, Based on the Logistic Function

Joseph Berkson · Journal of the American Statistical Association · 1953 · 392 citations

Public Health, Biostatistics, Dose-response Modeling +9

Estimation of Microquantities of Cyanide

Joseph Epstein · Analytical Chemistry · 1947 · 340 citations

Natural Sciences, Chemistry, Analytical Chemistry +5

Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease.

Akitaka Shibuya, A Yoshida · PubMed · 1988 · 124 citations

Life Sciences, Genetics, Molecular Genetics +15

Evidence for nitroxyl in the catalase-mediated bioactivation of the alcohol deterrent agent cyanamide

H. Nagasawa, Eugene G. DeMaster, Beth Redfern et al. · Journal of Medicinal Chemistry · 1990 · 122 citations

Pharmacy, Pharmacology, Toxicology +6